The Role of Notch3 Signaling in Kidney Disease
Joint Authors
Yuan, Cheng
Ni, Lihua
Zhang, Changjiang
Wu, Xiaoyan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Notch receptors are transmembrane proteins that are members of the epidermal growth factor-like family.
These receptors are widely expressed on the cell surface and are highly conserved.
Binding to ligands on adjacent cells results in cleavage of these receptors, and their intracellular domains translocate into the nucleus, where target gene transcription is initiated.
In the mammalian kidney, Notch receptors are activated during nephrogenesis and become silenced in the normal kidney after birth.
Reactivation of Notch signaling in the adult kidney could be due to the genetic activation of Notch signaling or kidney injury.
Notch3 is a mammalian heterodimeric transmembrane receptor in the Notch gene family.
Notch3 activation is significantly increased in various glomerular diseases, renal tubulointerstitial diseases, glomerular sclerosis, and renal fibrosis and mediates disease occurrence and development.
Here, we discuss numerous recently published papers describing the role of Notch3 signaling in kidney disease.
American Psychological Association (APA)
Yuan, Cheng& Ni, Lihua& Zhang, Changjiang& Wu, Xiaoyan. 2020. The Role of Notch3 Signaling in Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1203827
Modern Language Association (MLA)
Yuan, Cheng…[et al.]. The Role of Notch3 Signaling in Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1203827
American Medical Association (AMA)
Yuan, Cheng& Ni, Lihua& Zhang, Changjiang& Wu, Xiaoyan. The Role of Notch3 Signaling in Kidney Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1203827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203827