Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature
Joint Authors
Garcia-Rivas, Gerardo
Vázquez-Garza, Eduardo
Torre-Amione, Guillermo
Ramos-González, Martín R.
Bernal-Ramírez, Judith
Jerjes-Sánchez, Carlos
Lozano, Omar
Acuña-Morín, Edgar
Vanoye-Tamez, Mariana
Chapoy-Villanueva, Héctor
Pérez-Plata, Luis
Sánchez-Trujillo, Luis
Ramírez-Rivera, Alicia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pulmonary arterial hypertension (PAH) is a life-threatening disease that is characterized by an increase in pulmonary vascular pressure, leading to ventricular failure and high morbidity and mortality.
Resveratrol, a phenolic compound and a sirtuin 1 pathway activator, has known dietary benefits and is used as a treatment for anti-inflammatory and cardiovascular diseases.
Its therapeutic effects have been published in the scientific literature; however, its benefits in PAH are yet to be precisely elucidated.
Using a murine model of PAH induced by monocrotaline, the macroscopic and microscopic effects of a daily oral dose of resveratrol in rats with PAH were evaluated by determining its impact on the lungs and the right and left ventricular function.
While most literature has focused on smooth muscle cell mechanisms and lung pathology, our results highlight the relevance of therapy-mediated improvement of right ventricle and isolated cardiomyocyte physiology in both ventricles.
Although significant differences in the pulmonary architecture were not identified either micro- or macroscopically, the effects of resveratrol on right ventricular function and remodeling were observed to be beneficial.
The values for the volume, diameter, and contractility of the right ventricular cardiomyocytes returned to those of the control group, suggesting that resveratrol has a protective effect against ventricular dysfunction and pathological remodeling changes in PAH.
The effect of resveratrol in the right ventricle delayed the progression of findings associated with right heart failure and had a limited positive effect on the architecture of the lungs.
The use of resveratrol could be considered a future potential adjunct therapy, especially when the challenges to making a diagnosis and the current therapy limitations for PAH are taken into consideration.
American Psychological Association (APA)
Vázquez-Garza, Eduardo& Bernal-Ramírez, Judith& Jerjes-Sánchez, Carlos& Lozano, Omar& Acuña-Morín, Edgar& Vanoye-Tamez, Mariana…[et al.]. 2020. Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203838
Modern Language Association (MLA)
Vázquez-Garza, Eduardo…[et al.]. Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203838
American Medical Association (AMA)
Vázquez-Garza, Eduardo& Bernal-Ramírez, Judith& Jerjes-Sánchez, Carlos& Lozano, Omar& Acuña-Morín, Edgar& Vanoye-Tamez, Mariana…[et al.]. Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203838