Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy
Joint Authors
Jiang, Yanfang
Gao, Pujun
Hou, Jie
Zhang, Manli
Ding, Yuhong
Wang, Xinrui
Li, Tao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN).
Methods.
A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study.
The monocyte subset counts in circulation were measured by flow cytometry, and serum interleukin- (IL-) 10 and IL-12 concentrations were tested by enzyme-linked immunosorbent assay.
The potential association between clinical signs and monocyte subset counts was analyzed statistically.
Results.
Compared with the HCs, the patients with early stage of IMN had higher counts of CD14+CD163+, CD14+CD163+CD206+, and CD14+CD163+CD206+CD115+ M2-like monocytes.
The CD14+CD163+CD206+ M2-like cell counts and intracellular IL-10 concentrations in the monocytes were positively correlated with progression in proteinuria.
The levels of serum IL-10 were significantly higher in early IMN patients than in the HCs.
Furthermore, CD14+CD163+CD206+ M2-like cell counts in the patients with incipient IMN were also positively related with 24 h urinary albumin levels and the values of serum M-type phospholipase A2 receptor (PLA2R).
Conclusion.
CD14+CD163+CD206+ M2-like monocytes may contribute to the pathologic process in early-stage IMN and could serve as potential markers for evaluating the disease severity.
American Psychological Association (APA)
Hou, Jie& Zhang, Manli& Ding, Yuhong& Wang, Xinrui& Li, Tao& Gao, Pujun…[et al.]. 2018. Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203865
Modern Language Association (MLA)
Hou, Jie…[et al.]. Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203865
American Medical Association (AMA)
Hou, Jie& Zhang, Manli& Ding, Yuhong& Wang, Xinrui& Li, Tao& Gao, Pujun…[et al.]. Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203865