Critical Roles of IL-33ST2 Pathway in Neurological Disorders
Joint Authors
Ibraheem, Zaid O.
Basir, Rusliza
Majid, Roslaini Abd.
Chin, Voon Kin
Abd Rachman Isnadi, Mohammad Faruq
Lee, Tze Yan
Atmadini Abdullah, Maizaton
Bello Omenesa, Ramatu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself.
Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with ST2 variants.
IL-33 is a potent inducer for the Th2 immune response which includes defence mechanism in brain diseases.
Thus, in this paper, we review the biological features of IL-33 and the critical roles of IL-33/ST2 pathway in selected neurological disorders including Alzheimer’s disease, multiple sclerosis, and malaria infection to discuss the involvement of IL-33/ST2 pathway during these brain diseases and its potential as future immunotherapeutic agents or for intervention purposes.
American Psychological Association (APA)
Abd Rachman Isnadi, Mohammad Faruq& Chin, Voon Kin& Majid, Roslaini Abd.& Lee, Tze Yan& Atmadini Abdullah, Maizaton& Bello Omenesa, Ramatu…[et al.]. 2018. Critical Roles of IL-33ST2 Pathway in Neurological Disorders. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203870
Modern Language Association (MLA)
Abd Rachman Isnadi, Mohammad Faruq…[et al.]. Critical Roles of IL-33ST2 Pathway in Neurological Disorders. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203870
American Medical Association (AMA)
Abd Rachman Isnadi, Mohammad Faruq& Chin, Voon Kin& Majid, Roslaini Abd.& Lee, Tze Yan& Atmadini Abdullah, Maizaton& Bello Omenesa, Ramatu…[et al.]. Critical Roles of IL-33ST2 Pathway in Neurological Disorders. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203870
