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Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
Joint Authors
Xu, Jinwen
Zhou, Yi-Ting
Zhu, Lin
Yuan, Yunyun
Ling, Shuang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-18
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP).
SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases.
Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis.
Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone.
In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae.
Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.
American Psychological Association (APA)
Zhou, Yi-Ting& Zhu, Lin& Yuan, Yunyun& Ling, Shuang& Xu, Jinwen. 2020. Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1203885
Modern Language Association (MLA)
Zhou, Yi-Ting…[et al.]. Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1203885
American Medical Association (AMA)
Zhou, Yi-Ting& Zhu, Lin& Yuan, Yunyun& Ling, Shuang& Xu, Jinwen. Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1203885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203885