The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance
Joint Authors
Du, Yarong
Pan, Dong
Jia, Rong
Chen, Yaxiong
Jia, Cong
Wang, Jufang
Hu, Burong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although the mitochondrial antiviral signaling protein (MAVS), located in the mitochondrial outmembrane, is believed to be a signaling adaptor with antiviral feature firstly, it has been shown that suppression of MAVS enhanced radioresistance.
The mechanisms underlying this radioresistance remain unclear.
Our current study demonstrated that knockdown of MAVS alleviated the radiation-induced mitochondrial dysfunction (mitochondrial membrane potential disruption and ATP production), downregulated the expressions of proapoptotic proteins, and reduced the generation of ROS in cells after irradiation.
Furthermore, inhibition of mitochondrial ROS by the mitochondria-targeted antioxidant MitoQ reduced amounts of oligomerized MAVS after irradiation compared with the control group and also prevented the incidence of MN and increased the survival fraction of normal A549 cells after irradiation.
To our knowledge, it is the first report to indicate that MAVS, an innate immune signaling molecule, is involved in radiation response via its oligomerization mediated by radiation-induced ROS, which may be a potential target for the precise radiotherapy or radioprotection.
American Psychological Association (APA)
Du, Yarong& Pan, Dong& Jia, Rong& Chen, Yaxiong& Jia, Cong& Wang, Jufang…[et al.]. 2020. The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1203890
Modern Language Association (MLA)
Du, Yarong…[et al.]. The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1203890
American Medical Association (AMA)
Du, Yarong& Pan, Dong& Jia, Rong& Chen, Yaxiong& Jia, Cong& Wang, Jufang…[et al.]. The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1203890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203890