Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01
Joint Authors
Zheng, Lan
Ma, Yaohong
Zhang, Yunjuan
Meng, Qingjun
Yang, Junhui
Gong, Weili
Liu, Qingai
Cai, Lei
Hao, Lujiang
Wang, Binglian
Yang, Yan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This study demonstrates that Thelephora ganbajun had a strong ability to absorb zinc, and zinc can be compartmentally stored in the small vesicles and mainly accumulated in the form of zinc-enriched polysaccharides (zinc content was 25.0±1.27 mg/g).
Mycelia zinc polysaccharides (MZPS) and its fractions were isolated.
The main fraction (MZPS-2) with the highest antioxidant activity in vitro was composed of mannose : galacturonic acid : glucose : galactose in a molar ratio of 61.19 : 1 : 39.67 : 48.67, with a weight-averaged molecular weight of 5.118×105 Da.
MZPS-2 had both α-pyranose and β-pyranose configuration and had a triple helical conformation.
By establishing zebrafish models, we found that MZPS-2 can significantly scavenge free radicals, reduce the generation of reactive oxygen species caused by inflammation, and inhibit the recruitment of neutrophils toward the injury site.
Therefore, MZPS-2 exhibited antioxidant and anti-inflammatory effects and can be used as a zinc supplement with specific biological activities to alleviate zinc deficiency complications, such as chronic oxidative stress or inflammation.
American Psychological Association (APA)
Zheng, Lan& Ma, Yaohong& Zhang, Yunjuan& Meng, Qingjun& Yang, Junhui& Gong, Weili…[et al.]. 2020. Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1203901
Modern Language Association (MLA)
Zheng, Lan…[et al.]. Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1203901
American Medical Association (AMA)
Zheng, Lan& Ma, Yaohong& Zhang, Yunjuan& Meng, Qingjun& Yang, Junhui& Gong, Weili…[et al.]. Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1203901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203901