![](/images/graphics-bg.png)
Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis
Joint Authors
Chai, Yan-Fen
Gao, Yu-Lei
Zhai, Jian-Hua
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sepsis is recognized as a life-threatening organ dysfunctional disease that is caused by dysregulated host responses to infection.
Up to now, sepsis still remains a dominant cause of multiple organ dysfunction syndrome (MODS) and death among severe condition patients.
Pyroptosis, originally named after the Greek words “pyro” and “ptosis” in 2001, has been defined as a specific programmed cell death characterized by release of inflammatory cytokines.
During sepsis, pyroptosis is required for defense against bacterial infection because appropriate pyroptosis can minimize tissue damage.
Even so, pyroptosis when overactivated can result in septic shock, MODS, or increased risk of secondary infection.
Proteolytic cleavage of gasdermin D (GSDMD) by caspase-1, caspase-4, caspase-5, and caspase-11 is an essential step for the execution of pyroptosis in activated innate immune cells and endothelial cells stimulated by cytosolic lipopolysaccharide (LPS).
Cleaved GSDMD also triggers NACHT, LRR, and PYD domain-containing protein (NLRP) 3-mediated activation of caspase-1 via an intrinsic pathway, while the precise mechanism underlying GSDMD-induced NLRP 3 activation remains unclear.
Hence, this study provides an overview of the recent advances in the molecular mechanisms underlying pyroptosis in sepsis.
American Psychological Association (APA)
Gao, Yu-Lei& Zhai, Jian-Hua& Chai, Yan-Fen. 2018. Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203905
Modern Language Association (MLA)
Gao, Yu-Lei…[et al.]. Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203905
American Medical Association (AMA)
Gao, Yu-Lei& Zhai, Jian-Hua& Chai, Yan-Fen. Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203905