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In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz
Joint Authors
Farcaș, Anca D.
Moț, Augustin C.
Pârvu, Alina E.
Toma, Vlad Al.
Popa, Mirel A.
Mihai, Maria C.
Sevastre, Bogdan
Roman, Ioana
Vlase, Laurian
Pârvu, Marcel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Known for centuries throughout the world, Plantago species have long been used as traditional herbal remedies for many diseases related to inflammatory conditions of the skin, respiratory and digestive tract, or even malignancy.
This study is aimed first at investigating the in vitro antioxidant and regenerative effects of Plantago sempervirens Crantz hydroalcoholic extract followed by an in vivo experiment using a turpentine oil-induced inflammation model.
The in vitro evaluation for antioxidant activity was performed using classical assays such as DPPH and TEAC scavenging assays but also EPR, and the total phenolic content was determined using the Folin-Ciocalteu reagent.
The wound healing assay was performed on human cells (Human EA.hy926).
Besides, the prooxidant activity was determined using a method which involves in situ free radical generation by laccase and the oxidation of haemoglobin.
On turpentine oil-induced inflammation in rats, the in vivo effects of three doses of P.
sempervirens extracts (100%, 50%, and 25%) were assessed by measuring oxidative stress (MDA, TOS, OSI, NO, CAT, and SOD) and inflammatory (CRP, WBC, and NEU) parameters.
Having a rich polyphenolic content, the xerophyte P.
sempervirens exhibited a strong in vitro antioxidant activity by scavenging radicals, enhancing cell regeneration, and reducing oxidative stress markers.
Diluted P.
sempervirens extract (25%) exhibited the best antioxidant, wound healing, and anti-inflammatory activity.
American Psychological Association (APA)
Farcaș, Anca D.& Moț, Augustin C.& Pârvu, Alina E.& Toma, Vlad Al.& Popa, Mirel A.& Mihai, Maria C.…[et al.]. 2019. In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203912
Modern Language Association (MLA)
Farcaș, Anca D.…[et al.]. In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1203912
American Medical Association (AMA)
Farcaș, Anca D.& Moț, Augustin C.& Pârvu, Alina E.& Toma, Vlad Al.& Popa, Mirel A.& Mihai, Maria C.…[et al.]. In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203912