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Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses
Joint Authors
Cassol, Edana
Ahmed, Duale
Jaworski, Allison
Roy, David
Willmore, William
Golshani, Ashkan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Emerging evidence suggests that cellular metabolism plays a critical role in regulating immune activation.
Alterations in energy and lipid and amino acid metabolism have been shown to contribute to type I interferon (IFN) responses in macrophages, but the relationship between metabolic reprogramming and the establishment of early antiviral function remains poorly defined.
Here, we used transcriptional profiling datasets to develop global metabolic signatures associated with early IFN-α responses in two primary macrophage model systems: mouse bone marrow-derived macrophages (BMM) and human monocyte-derived macrophages (MDM).
Short-term stimulation with IFN-α (<4 hours) was associated with significant metabolic rewiring, with >500 metabolic genes altered in mouse and human macrophage models.
Pathway and network analysis identified alterations in genes associated with cellular bioenergetics, cellular oxidant status, cAMP/AMP and cGMP/GMP ratios, branched chain amino acid catabolism, cell membrane composition, fatty acid synthesis, and β-oxidation as key features of early IFN-α responses.
These changes may have important implications for initial establishment of antiviral function in these cells.
American Psychological Association (APA)
Ahmed, Duale& Jaworski, Allison& Roy, David& Willmore, William& Golshani, Ashkan& Cassol, Edana. 2018. Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1203925
Modern Language Association (MLA)
Ahmed, Duale…[et al.]. Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses. Mediators of Inflammation No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1203925
American Medical Association (AMA)
Ahmed, Duale& Jaworski, Allison& Roy, David& Willmore, William& Golshani, Ashkan& Cassol, Edana. Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1203925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203925