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Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis
Joint Authors
Tang, Chaoliang
Zhang, Zhetao
Jiang, Lai
Gong, Yanping
Hu, Yida
You, Yangyang
Wang, Jiawu
Wei, Zeyuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Previous research has shown that peroxiredoxin 1 (Prdx1) is an important modulator of physiological and pathophysiological cardiovascular events.
This study is aimed at investigating the role and underlying mechanism of Prdx1 in doxorubicin- (DOX-) induced cardiotoxicity.
Cardiac-specific expression of Prdx1 was induced in mice, and the mice received a single dose of DOX (15 mg/kg) to generate cardiotoxicity.
First, our study demonstrated that Prdx1 expression was upregulated in the heart and in cardiomyocytes after DOX treatment.
Second, we provided direct evidence that Prdx1 overexpression ameliorated DOX-induced cardiotoxicity by attenuating oxidative stress and cardiomyocyte apoptosis.
Mechanistically, we found that DOX treatment increased the phosphorylation level of apoptosis signal-regulating kinase-1 (ASK1) and the downstream protein p38 in the heart and in cardiomyocytes, and these effects were decreased by Prdx1 overexpression.
In contrast, inhibiting Prdx1 promoted DOX-induced cardiac injury via the ASK1/p38 pathway.
These results suggest that Prdx1 may be an effective therapeutic option to prevent DOX-induced cardiotoxicity.
American Psychological Association (APA)
Jiang, Lai& Gong, Yanping& Hu, Yida& You, Yangyang& Wang, Jiawu& Zhang, Zhetao…[et al.]. 2020. Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203933
Modern Language Association (MLA)
Jiang, Lai…[et al.]. Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1203933
American Medical Association (AMA)
Jiang, Lai& Gong, Yanping& Hu, Yida& You, Yangyang& Wang, Jiawu& Zhang, Zhetao…[et al.]. Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203933