Potential Effect of SOX2 on the Cell Cycle of Wharton’s Jelly Stem Cells (WJSCs)
Joint Authors
Kocki, Janusz
Gil-Kulik, Paulina
Krzyżanowski, Arkadiusz
Kwaśniewska, Anna
Świstowska, Małgorzata
Bielecki, Tomasz
Czop, Marcin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The connective tissue of the umbilical cord contains stem cells called Wharton’s jelly cells.
These cells express core transcription factors (NANOG, OCT4, and SOX2).
The protein product of the SOX2 gene controls the cell cycle by interacting with cyclin D (directly and indirectly) and cycle inhibitors—p21 and p27, as well as two E2f3 protein isoforms.
The aim of the study was to analyze the effect of SOX2 on the cell cycle of stem cells of Wharton’s jelly.
The material for the study was the stem cells of Wharton’s jelly isolated from 20 umbilical cords collected during childbirth.
The stem cells collected were subjected to cytometric analysis, cell culture, and RNA isolation.
cDNA was the starting material for the analysis of gene expression: SOX2, CCND1, CDK4, and CDKN1B.
The studies indicate a high proliferative potential of the Wharton’s jelly stem cells and the inhibitory effect of SOX2 on the expression of the CCND1 and CDK4 gene.
American Psychological Association (APA)
Świstowska, Małgorzata& Gil-Kulik, Paulina& Krzyżanowski, Arkadiusz& Bielecki, Tomasz& Czop, Marcin& Kwaśniewska, Anna…[et al.]. 2019. Potential Effect of SOX2 on the Cell Cycle of Wharton’s Jelly Stem Cells (WJSCs). Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1203937
Modern Language Association (MLA)
Świstowska, Małgorzata…[et al.]. Potential Effect of SOX2 on the Cell Cycle of Wharton’s Jelly Stem Cells (WJSCs). Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1203937
American Medical Association (AMA)
Świstowska, Małgorzata& Gil-Kulik, Paulina& Krzyżanowski, Arkadiusz& Bielecki, Tomasz& Czop, Marcin& Kwaśniewska, Anna…[et al.]. Potential Effect of SOX2 on the Cell Cycle of Wharton’s Jelly Stem Cells (WJSCs). Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1203937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203937