The Role of Immunosenescence in Neurodegenerative Diseases
Joint Authors
D’Angelo, C.
Costantini, E.
Reale, Marcella
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death.
Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in the number of circulating monocytic and dendritic cells, thymic involution, T cell polyfunctionality, or production of proinflammatory cytokines, and are defined as immunosenescence.
Inflammatory functions are increased with age, causing the chronic low-grade inflammation, referred to as inflamm-aging, that contribute, together with immunosenescence, to neurodegenerative diseases.
In this review, we discuss the link between the immune and nervous systems and how the immunosenescence and inflamm-aging can contribute to neurodegenerative diseases.
American Psychological Association (APA)
Costantini, E.& D’Angelo, C.& Reale, Marcella. 2018. The Role of Immunosenescence in Neurodegenerative Diseases. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203950
Modern Language Association (MLA)
Costantini, E.…[et al.]. The Role of Immunosenescence in Neurodegenerative Diseases. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203950
American Medical Association (AMA)
Costantini, E.& D’Angelo, C.& Reale, Marcella. The Role of Immunosenescence in Neurodegenerative Diseases. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203950