Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner
Joint Authors
Liu, Zhaoguo
Yan, Tingdong
Yao, Wenjuan
Chen, Tingting
Chen, Chang
Wang, Jue
Gu, Jingya
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Sirtuin 3 (SIRT3) is a deacetylase involved in the development of many inflammation-related diseases including liver fibrosis.
Withaferin A (WFA) is a bioactive constituent derived from the Withania somnifera plant, which has extensive pharmacological activities; however, little is known about the regulatory role of SIRT3 in the WFA-induced antifibrogenic effect.
The current study is aimed at investigating the role of SIRT3 in WFA-induced antioxidant effects in liver fibrosis.
Our study verified that WFA attenuated platelet-derived growth factor BB- (PDGF-BB-) induced liver fibrosis and promoted PDGF-BB-induced SIRT3 activity and expression in JS1 cells.
SIRT3 silencing attenuated the antifibrogenic and antioxidant effects of WFA in activated JS1 cells.
Moreover, WFA inhibited carbon tetrachloride- (CCl4-) induced liver injury, collagen deposition, and fibrosis; increased the SIRT3 expression; and suppressed the CCl4-induced oxidative stress in fibrotic livers of C57/BL6 mice.
Furthermore, the antifibrogenic and antioxidant effects of WFA could be available in CCl4-induced WT (129S1/SvImJ) mice but were unavailable in CCl4-induced SIRT3 knockout (KO) mice.
Our study suggested that WFA inhibited liver fibrosis through the inhibition of oxidative stress in a SIRT3-dependent manner.
WFA could be a potential compound for the treatment of liver fibrosis.
American Psychological Association (APA)
Gu, Jingya& Chen, Chang& Wang, Jue& Chen, Tingting& Yao, Wenjuan& Yan, Tingdong…[et al.]. 2020. Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1203951
Modern Language Association (MLA)
Gu, Jingya…[et al.]. Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1203951
American Medical Association (AMA)
Gu, Jingya& Chen, Chang& Wang, Jue& Chen, Tingting& Yao, Wenjuan& Yan, Tingdong…[et al.]. Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1203951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203951