Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking
Joint Authors
Monteiro, Marta Chagas
Fontes-Júnior, Enéas Andrade
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Luz, Diandra Araújo
Gomes, Antônio Rafael Quadros
Nascimento, Chirlene Pinheiro
da Silva, Carla Cristiane Soares
Malcher, Cláudia Marques Rosa
Dalla Santa, Herta Stutz
Ribeiro, Carolina Heitmann Mares Azevedo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System.
Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities.
On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period.
In this study, we investigated whether the Aqueous Extract of G.
lucidum (AEGl) reduces the behavioral disorders induced by alcohol.
Male (n=30) and female Wistar rats (n=40), seventy-two days old, were used for behavioral/biochemical and oral toxicity test, respectively.
Animals were exposed to 5 binges (beginning at 35 days old) of ethanol (3 g/kg/day) or distilled water.
Twenty-four hours after the last binge administration, animals received AEGl (100 mg/kg/day) or distilled water for three consecutive days.
After treatment protocol, open field, elevated plus maze, forced swim, and step-down inhibitory avoidance tests were performed.
Oxidative stress parameters were measured to evaluate the REDOX balance.
Our results demonstrated that AEGl elicited the recovery of spontaneous horizontal exploration capacity, anxiogenic- and depressive-profile, as well as short-term memory damage induced by binge-ethanol exposure.
The behavioral effects of the extract were associated to the reequilibrium of the animals’ REDOX balance.
Thus, AEGl, a medicinal mushroom, ameliorates behavioral alteration on a model of motor, cognitive and psychiatric-like disorders induced by binge drinking paradigm and emerges as a useful tool as a food supplement in the management of disorders of alcoholic origin.
American Psychological Association (APA)
Nascimento, Chirlene Pinheiro& Luz, Diandra Araújo& da Silva, Carla Cristiane Soares& Malcher, Cláudia Marques Rosa& Fernandes, Luanna Melo Pereira& Dalla Santa, Herta Stutz…[et al.]. 2020. Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1203977
Modern Language Association (MLA)
Nascimento, Chirlene Pinheiro…[et al.]. Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1203977
American Medical Association (AMA)
Nascimento, Chirlene Pinheiro& Luz, Diandra Araújo& da Silva, Carla Cristiane Soares& Malcher, Cláudia Marques Rosa& Fernandes, Luanna Melo Pereira& Dalla Santa, Herta Stutz…[et al.]. Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1203977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203977