![](/images/graphics-bg.png)
Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics
Joint Authors
Zelante, Teresa
Puccetti, Matteo
Paolicelli, Giuseppe
De Luca, Antonella
Renga, Giorgia
Borghi, Monica
Pariano, Marilena
Stincardini, Claudia
Romani, Luigina
Costantini, Claudio
Bartoli, Andrea
Oikonomou, Vasileios
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phagocytes fight fungi using canonical and noncanonical, also called LC3-associated phagocytosis (LAP), autophagy pathways.
However, the outcomes of autophagy/LAP in shaping host immune responses appear to greatly vary depending on fungal species and cell types.
By allowing efficient pathogen clearance and/or degradation of inflammatory mediators, autophagy proteins play a broad role in cellular and immune homeostasis during fungal infections.
Indeed, defects in autophagic machinery have been linked with aberrant host defense and inflammatory states.
Thus, understanding the molecular mechanisms underlying the relationship between the different forms of autophagy may offer a way to identify drugable molecular signatures discriminating between selective recognition of cargo and host protection.
In this regard, IFN-γ and anakinra are teaching examples of successful antifungal agents that target the autophagy machinery.
This article provides an overview of the role of autophagy/LAP in response to fungi and in their infections, regulation, and therapeutic exploitation.
American Psychological Association (APA)
Oikonomou, Vasileios& Renga, Giorgia& De Luca, Antonella& Borghi, Monica& Pariano, Marilena& Puccetti, Matteo…[et al.]. 2018. Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203993
Modern Language Association (MLA)
Oikonomou, Vasileios…[et al.]. Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203993
American Medical Association (AMA)
Oikonomou, Vasileios& Renga, Giorgia& De Luca, Antonella& Borghi, Monica& Pariano, Marilena& Puccetti, Matteo…[et al.]. Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203993