Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy.
Accumulating evidence suggests that neuroinflammation plays a critical role in POCD.
After surgery, alarmins are leaked from the injury sites and proinflammatory cytokines are increased in the peripheral circulation.
Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma.
Microglia, bone marrow-derived macrophages, mast cells, and T cells in the central nervous system (CNS) can be activated to secrete more cytokines, further aggravating neuroinflammation after surgery.
Conversely, blocking the inflammation network between these immune cells and related cytokines alleviates POCD in experimental animals.
Thus, a deeper understanding of the roles of immune cells and the crosstalk between them in POCD may uncover promising therapeutic targets for POCD treatment and prevention.
Here, we reviewed several major immune cells and discussed their functional roles in POCD.
American Psychological Association (APA)
Liu, Yue& Yin, Yiqing. 2018. Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204002
Modern Language Association (MLA)
Liu, Yue& Yin, Yiqing. Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1204002
American Medical Association (AMA)
Liu, Yue& Yin, Yiqing. Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204002