Vascular Inflammation Is a Risk Factor Associated with Brain Atrophy and Disease Severity in Parkinson’s Disease: A Case-Control Study
Joint Authors
Lin, Wei-Che
Chen, Meng-Hsiang
Chen, Hsiu-Ling
Yu, Chiun-Chieh
Tsai, Nai-Wen
Huang, Chih-Cheng
Lu, Cheng-Hsien
Chang, Yung-Yee
Li, Shau-Hsuan
Chen, Yueh-Sheng
Chiang, Pi-Ling
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Introduction.
Systemic inflammation with elevated oxidative stress causing neuroinflammation is considered a major factor in the pathogenesis of Parkinson’s disease (PD).
The interface between systemic circulation and the brain parenchyma is the blood-brain barrier (BBB), which also plays a role in maintaining neurovascular homeostasis.
Vascular cell adhesion molecule-1 (VCAM-1) and microRNAs (miRNAs) regulate brain vessel endothelial function, neoangiogenesis, and, in turn, neuronal homeostasis regulation, such that their dysregulation can result in neurodegeneration, such as gray matter atrophy, in PD.
Objective.
Our aim was to evaluate the associations among specific levels of gray matter atrophy, peripheral vascular adhesion molecules, miRNAs, and clinical disease severity in order to achieve a clearer understanding of PD pathogenesis.
Methods.
Blood samples were collected from 33 patients with PD and 27 healthy volunteers, and the levels of VCAM-1 and several miRNAs in those samples were measured.
Voxel-based morphometry (VBM) analysis was performed using 3 T magnetic resonance imaging (MRI) and SPM (Statistical Parametric Mapping software program).
The associations among the vascular parameter, miRNAs, gray matter volume, and clinical disease severity measurements were evaluated by partial correlation analysis.
Results.
The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients.
The gray matter volume atrophy in the left parahippocampus, bilateral posterior cingulate gyrus, fusiform gyrus, left temporal gyrus, and cerebellum was significantly correlated with increased clinical disease severity, the upregulation of miRNA levels, and increased vascular inflammation.
Conclusion.
Patients with PD seem to have abnormal levels of vascular inflammatory markers and miRNAs in the peripheral circulation, and these levels are correlated with specific brain volume changes.
This study reinforces the associations among peripheral inflammation, the BBB interface, and gray matter atrophy in PD and further demonstrates that BBB dysfunction with neurovascular impairment may play an important role in PD progression.
American Psychological Association (APA)
Yu, Chiun-Chieh& Chen, Hsiu-Ling& Chen, Meng-Hsiang& Lu, Cheng-Hsien& Tsai, Nai-Wen& Huang, Chih-Cheng…[et al.]. 2020. Vascular Inflammation Is a Risk Factor Associated with Brain Atrophy and Disease Severity in Parkinson’s Disease: A Case-Control Study. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204007
Modern Language Association (MLA)
Yu, Chiun-Chieh…[et al.]. Vascular Inflammation Is a Risk Factor Associated with Brain Atrophy and Disease Severity in Parkinson’s Disease: A Case-Control Study. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204007
American Medical Association (AMA)
Yu, Chiun-Chieh& Chen, Hsiu-Ling& Chen, Meng-Hsiang& Lu, Cheng-Hsien& Tsai, Nai-Wen& Huang, Chih-Cheng…[et al.]. Vascular Inflammation Is a Risk Factor Associated with Brain Atrophy and Disease Severity in Parkinson’s Disease: A Case-Control Study. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204007