Antioxidant Effects of Baoyuan Decoction on Dysfunctional Erythrocytes in High-Fat Diet-Induced Hyperlipidemic ApoE-- Mice
Joint Authors
Jiang, Yong
Zheng, Jiao
Zhao, Yunfang
Li, Jun
Tu, Peng-Fei
Wu, Zhen
Jin, Fengyu
Wang, Lingxiao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Baoyuan decoction (BYD), a traditional representative formula, has a long usage history in the treatment of cardiovascular diseases.
Since the hyperlipidemia-induced dysfunction of erythrocyte is one of the most important causes of cardiovascular diseases, the improving effects of BYD against high-fat diet (HFD) induced the physiological and physical function of the erythrocytic injury and the potential mechanisms were deeply researched in this study.
After 6 weeks of drug treatment, all doses of BYD had significantly decreased the lipid peroxidation in plasma of HFD-induced ApoE-/- mice, even if it had not improved the lipid levels.
Then, the erythrocyte-related experimental results showed that BYD had reduced erythrocyte osmotic fragility, stabilized erythrocyte membrane skeleton protein 4.2, and reformed the erythrocyte morphological changes by decreasing erythrocyte membrane lipid peroxidation levels.
This study demonstrated that BYD may ameliorate the physiological and physical function of erythrocyte in hyperlipidemic mice through the antioxidant effect on erythrocyte membranes.
American Psychological Association (APA)
Wu, Zhen& Jin, Fengyu& Wang, Lingxiao& Zhao, Yunfang& Jiang, Yong& Li, Jun…[et al.]. 2019. Antioxidant Effects of Baoyuan Decoction on Dysfunctional Erythrocytes in High-Fat Diet-Induced Hyperlipidemic ApoE-- Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204012
Modern Language Association (MLA)
Wu, Zhen…[et al.]. Antioxidant Effects of Baoyuan Decoction on Dysfunctional Erythrocytes in High-Fat Diet-Induced Hyperlipidemic ApoE-- Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204012
American Medical Association (AMA)
Wu, Zhen& Jin, Fengyu& Wang, Lingxiao& Zhao, Yunfang& Jiang, Yong& Li, Jun…[et al.]. Antioxidant Effects of Baoyuan Decoction on Dysfunctional Erythrocytes in High-Fat Diet-Induced Hyperlipidemic ApoE-- Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204012