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Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development
Joint Authors
Xu, Xuewen
Zhang, Xinyue
Gao, Linlin
Liu, Chunfeng
You, Kai
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-02
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Hyperoxia is essential to manage in preterm infants but causes injury to immature kidney.
Previous study indicates that hyperoxia causes oxidative damage to neonatal kidney and impairs renal development.
However, the underlying mechanisms by which neonatal hyperoxia effects on immature kidney still need to be elucidated.
Tight junction, among which the representative proteins are claudin-4, occludin, and ZO-1, plays a crucial role in nephrogenesis and maintaining renal function.
Inflammatory cytokines are involved in the pleiotropic regulation of tight junction proteins.
Here, we investigated how neonatal hyperoxia affected the expression of key tight junction proteins and inflammatory factors (IL-6 and TNF-α) in the developing rat kidneys and elucidated their correlation with renal injury.
We found claudin-4, occludin, and zonula occludens-1 (ZO-1) expression in proximal tubules was significantly downregulated after neonatal hyperoxia.
The expression of these tight junction proteins was positively correlated with that of IL-6 and TNF-α, while claudin-4 expression was positively correlated with injury score of proximal tubules in mature kidneys.
These findings indicated that impaired expression of tight junction proteins in kidney might be a potential mechanism of hyperoxia-induced nephrogenic disorders.
It provides new insights to further study oxidative renal injury and development disorders and will be helpful for seeking potential therapeutics for hyperoxia-induced renal injury in the future.
American Psychological Association (APA)
Xu, Xuewen& Zhang, Xinyue& Gao, Linlin& Liu, Chunfeng& You, Kai. 2020. Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1204015
Modern Language Association (MLA)
Xu, Xuewen…[et al.]. Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1204015
American Medical Association (AMA)
Xu, Xuewen& Zhang, Xinyue& Gao, Linlin& Liu, Chunfeng& You, Kai. Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1204015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204015