Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study
Joint Authors
Mangoni, Arduino A.
Di Sante, Gabriele
Ferraccioli, Gianfranco
Tolusso, Barbara
Gremese, Elisa
Piga, Matteo
Erre, Gian Luca
Cauli, Alberto
Fedele, Anna Laura
Mura, Silvia
Piras, Alessandra
Cadoni, Maria Luisa
Cangemi, Ignazio
Dessi, Martina
Saba, Pier Sergio
Mathieu, Alessandro
Passiu, Giuseppe
Carru, Ciriaco
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
To define the prevalence and determinants of peripheral microvascular endothelial dysfunction (ED) in a large series of rheumatoid arthritis (RA) patients free of previous cardiovascular events.
Materials and Methods.
Data from 874 RA patients enrolled in the EDRA study (Endothelial Dysfunction Evaluation for Coronary Heart Disease Risk Estimation in Rheumatoid Arthritis—ClinicalTrials.gov: NCT02341066) were analyzed.
Log-transformed reactive hyperemia index (Ln-RHI) was evaluated by peripheral arterial tonometry (PAT) using the EndoPAT2000 device: values of Ln-RHI < 0.51 were considered indicative of peripheral ED.
Results.
Peripheral microvascular ED was documented in one-third of RA patients (33.5%); in multiple logistic regression analysis, ACPA negativity and higher triglycerides concentrations were independently associated with the presence of peripheral ED [OR (95% CI) = 1.708 (1.218–2.396), p<0.01 and OR (95% CI) = 1.005 (1.002–1.009), p<0.01, respectively].
Multiple regression analysis showed a positive correlation between Ln-RHI values and systolic blood pressure and HDL cholesterol levels; furthermore, higher values of Ln-RHI were associated with ACPA positivity, while smoking habit was associated with lower Ln-RHI values.
Conclusions.
This study demonstrates for the first time a high prevalence of peripheral microvascular ED in patients with RA free of previous cardiovascular events that appear to be only partially driven by traditional cardiovascular risk factors.
The association between ACPA negativity and ED warrants further exploration.
American Psychological Association (APA)
Erre, Gian Luca& Piga, Matteo& Fedele, Anna Laura& Mura, Silvia& Piras, Alessandra& Cadoni, Maria Luisa…[et al.]. 2018. Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204037
Modern Language Association (MLA)
Erre, Gian Luca…[et al.]. Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1204037
American Medical Association (AMA)
Erre, Gian Luca& Piga, Matteo& Fedele, Anna Laura& Mura, Silvia& Piras, Alessandra& Cadoni, Maria Luisa…[et al.]. Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204037