Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells

Abstract EN

Human colon cancer is the third leading cause of mortality in the United States and worldwide.

Chemoprevention using diet is widely accepted as a promising approach for cancer management.

Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds.

In the current study, we evaluated the anticancer properties of a high phenolic sorghum bran extract prepared using 70% ethanol with 5% citric acid solvent at room temperature.

A significant dose-dependent suppression of cell proliferation was observed in human colon cancer cells treated with the high phenolic sorghum bran extract.

Apoptosis and S phase growth arrest were induced, while cell migration and invasion were inhibited by this treatment; these effects were accompanied by altered expression of apoptosis, cell cycle, and metastasis-regulating genes.

We also found that the high phenolic sorghum bran extract stimulated DNA damage in association with induction of extracellular signal-regulated kinase (ERK) and c-Jun-NH2-terminal kinase (JNK) and subsequent expression of activating transcription factor 3 (ATF3).

The present study expands our understanding of the potential use of high phenolic sorghum bran to prevent human colon cancer.