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Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells
Joint Authors
Lee, Jihye
Cox, Sarah
Noronha, Leela
Perumal, Ramasamy
Lee, Hee-Seop
Smolensky, Dmitriy
Herald, Thomas
Lee, Seong-Ho
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Human colon cancer is the third leading cause of mortality in the United States and worldwide.
Chemoprevention using diet is widely accepted as a promising approach for cancer management.
Numerous population studies indicate a negative correlation between the incidence of colon cancer and consumption of whole grains with a high content of bioactive phenolic compounds.
In the current study, we evaluated the anticancer properties of a high phenolic sorghum bran extract prepared using 70% ethanol with 5% citric acid solvent at room temperature.
A significant dose-dependent suppression of cell proliferation was observed in human colon cancer cells treated with the high phenolic sorghum bran extract.
Apoptosis and S phase growth arrest were induced, while cell migration and invasion were inhibited by this treatment; these effects were accompanied by altered expression of apoptosis, cell cycle, and metastasis-regulating genes.
We also found that the high phenolic sorghum bran extract stimulated DNA damage in association with induction of extracellular signal-regulated kinase (ERK) and c-Jun-NH2-terminal kinase (JNK) and subsequent expression of activating transcription factor 3 (ATF3).
The present study expands our understanding of the potential use of high phenolic sorghum bran to prevent human colon cancer.
American Psychological Association (APA)
Lee, Seong-Ho& Lee, Jihye& Herald, Thomas& Cox, Sarah& Noronha, Leela& Perumal, Ramasamy…[et al.]. 2020. Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204064
Modern Language Association (MLA)
Lee, Seong-Ho…[et al.]. Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204064
American Medical Association (AMA)
Lee, Seong-Ho& Lee, Jihye& Herald, Thomas& Cox, Sarah& Noronha, Leela& Perumal, Ramasamy…[et al.]. Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204064