Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress
Joint Authors
Juarranz, Ángeles
González, Salvador
Delgado-Wicke, Pablo
Rodríguez-Luna, Azahara
Ikeyama, Yoshifumi
Honma, Yoichi
Kume, Toshiaki
Gutierrez, María
Lorrio, Silvia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Humans in modern industrial and postindustrial societies face sustained challenges from environmental pollutants, which can trigger tissue damage from xenotoxic stress through different mechanisms.
Thus, the identification and characterization of compounds capable of conferring antioxidant effects and protection against these xenotoxins are warranted.
Here, we report that the natural extract of Polypodium leucotomos named Fernblock®, known to reduce aging and oxidative stress induced by solar radiations, upregulates the NRF2 transcription factor and its downstream antioxidant targets, and this correlates with its ability to reduce inflammation, melanogenesis, and general cell damage in cultured keratinocytes upon exposure to an experimental model of fine pollutant particles (PM2.5).
Our results provide evidence for a specific molecular mechanism underpinning the protective activity of Fernblock® against environmental pollutants and potentially other sources of oxidative stress and damage-induced aging.
American Psychological Association (APA)
Delgado-Wicke, Pablo& Rodríguez-Luna, Azahara& Ikeyama, Yoshifumi& Honma, Yoichi& Kume, Toshiaki& Gutierrez, María…[et al.]. 2020. Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204071
Modern Language Association (MLA)
Delgado-Wicke, Pablo…[et al.]. Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204071
American Medical Association (AMA)
Delgado-Wicke, Pablo& Rodríguez-Luna, Azahara& Ikeyama, Yoshifumi& Honma, Yoichi& Kume, Toshiaki& Gutierrez, María…[et al.]. Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204071