Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment
Joint Authors
Goh, Yan Mei
Antonowicz, Stefan S.
Boshier, Piers
Hanna, George B.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Introduction.
Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths.
Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority.
Metabolite quantitation is amenable to point-of-care analysis and can be performed in ASCC surrogates such as breath and saliva.
The purpose of this systematic review is to summarise progress of ASCC metabolomic studies, with an emphasis on the critical appraisal of methodological quality and reporting.
Method.
A systematic online literature search was performed to identify studies reporting metabolic biomarkers of ASCC.
This review was conducted in accordance with the recommendations of the Cochrane Library and MOOSE guidelines.
Results.
Thirty studies comprising 2117 patients were included in the review.
All publications represented phase-I biomarker discovery studies, and none validated their findings in an independent cohort.
There was heterogeneity in study design and methodological and reporting quality.
Sensitivities and specificities were higher in oesophageal and head and neck squamous cell carcinomas compared to those in lung squamous cell carcinoma.
The metabolic phenotypes of these cancers were similar, as was the kinetics of metabolite groups when comparing blood, tissue, and breath/saliva concentrations.
Deregulation of amino acid metabolism was the most frequently reported theme.
Conclusion.
Metabolite analysis has shown promising diagnostic performance, especially for oesophageal and head and neck ASCC subtypes, which are phenotypically similar.
However, shortcomings in study design have led to inconsistencies between studies.
To support future studies and ultimately clinical adoption, these limitations are discussed.
American Psychological Association (APA)
Goh, Yan Mei& Antonowicz, Stefan S.& Boshier, Piers& Hanna, George B.. 2020. Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204075
Modern Language Association (MLA)
Goh, Yan Mei…[et al.]. Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204075
American Medical Association (AMA)
Goh, Yan Mei& Antonowicz, Stefan S.& Boshier, Piers& Hanna, George B.. Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204075