RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo
Joint Authors
Wu, Wenxin
Wang, Xiaoqiu
Zhang, Wei
Tian, Lili
Booth, J. Leland
Duggan, Elizabeth S.
More, Sunil
Liu, Lin
Dozmorov, Mikhail
Metcalf, Jordan P.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines.
It requires interaction with an adaptor molecule, mitochondrial antiviral-signaling protein (MAVS), to activate downstream signaling pathways.
To elucidate the mechanism(s) by which RIG-I-dependent recognition of IAV infection in vivo triggers innate immune responses, we infected mutant mice lacking RIG-I or MAVS with influenza A virus (IAV) and measured their innate immune responses.
As has previously been demonstrated with isolated deletion of the virus recognition receptors TLR3, TLR7, and NOD2, RIG-I or MAVS knockout (KO) did not result in higher mortality and did not reduce IAV-induced cytokine responses in mice.
Infected RIG-I KO animals displayed similar lung inflammation profiles as did WT mice, in terms of the protein concentration, total cell count, and inflammatory cell composition in the bronchoalveolar lavage fluid.
RNA-Seq results demonstrated that all types of mice exhibited equivalent antiviral and inflammatory gene responses following IAV infection.
Together, the results indicated that although RIG-I is important in innate cytokine responses in vitro, individual deletion of the genes encoding RIG-I or MAVS did not change survival or innate responses in vivo after IAV infection in mice.
American Psychological Association (APA)
Wu, Wenxin& Wang, Xiaoqiu& Zhang, Wei& Tian, Lili& Booth, J. Leland& Duggan, Elizabeth S.…[et al.]. 2018. RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204084
Modern Language Association (MLA)
Wu, Wenxin…[et al.]. RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo. Mediators of Inflammation No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1204084
American Medical Association (AMA)
Wu, Wenxin& Wang, Xiaoqiu& Zhang, Wei& Tian, Lili& Booth, J. Leland& Duggan, Elizabeth S.…[et al.]. RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204084