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Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia
Joint Authors
Wang, Guo-qing
Li, Jing-jie
He, Xue-mei
Zhou, Yan-zhen
Sheng, Shuo
Zhang, Feng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Neuroinflammation plays a crucial role in the pathological process of Parkinson’s disease (PD).
Nod-like receptor protein 3 (NLRP3) inflammasome was highly located in microglia and involved in the process of neuroinflammation.
Activation of the NLRP3 inflammasome has been confirmed to contribute to the progression of PD.
Thus, inhibition of NLRP3 inflammasome activation could be an important breakthrough point on PD therapy.
Ellagic acid (EA) is a natural polyphenol that has been widely found in soft fruits, nuts, and other plant tissues with anti-inflammatory, antioxidant, and neuroprotective properties.
However, the mechanisms underlying EA-mediated anti-inflammation and neuroprotection have not been fully elucidated.
In this study, a lipopolysaccharide- (LPS-) induced rat dopamine (DA) neuronal damage model was performed to determine the effects of EA on the protection of DA neurons.
In addition, the DA neuronal MN9D cell line and microglial BV-2 cell line were employed to explore whether EA-mediated neuroprotection was through an NLRP3-dependent mechanism.
Results indicated that EA ameliorated LPS-induced DA neuronal loss in the rat substantia nigra.
Further, inhibition of microglial NLRP3 inflammasome signaling activation was involved in EA-generated neuroprotection, as evidenced by the following observations.
First, EA reduced NLRP3 inflammasome signaling activation in microglia and subsequent proinflammatory cytokines’ excretion.
Second, EA-mediated antineuroinflammation and further DA neuroprotection from LPS-induced neurotoxicity were not shown upon microglial NLRP3 siRNA treatment.
In conclusion, this study demonstrated that EA has a profound effect on protecting DA neurons against LPS-induced neurotoxicity via the suppression of microglial NLRP3 inflammasome activation.
American Psychological Association (APA)
He, Xue-mei& Zhou, Yan-zhen& Sheng, Shuo& Li, Jing-jie& Wang, Guo-qing& Zhang, Feng. 2020. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204089
Modern Language Association (MLA)
He, Xue-mei…[et al.]. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204089
American Medical Association (AMA)
He, Xue-mei& Zhou, Yan-zhen& Sheng, Shuo& Li, Jing-jie& Wang, Guo-qing& Zhang, Feng. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204089