IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice
Joint Authors
Waga, Kengo
Yamaguchi, Masaru
Miura, Shuta
Nishida, Teruki
Itai, Akiko
Nakanishi, Reiko
Kashiwakura, Ikuo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nuclear factor-kappa B (NF-κB) transcription factor plays a critical role in regulating radiation-induced inflammatory and immune responses.
Intracellular reactive oxygen species generation induces the activation of NF-κB via the inhibitor of κB (IκB) kinase (IKK) complex signaling.
Previous studies have reported that the inhibition of IKK-driven NF-κB activation offers a therapeutic strategy for managing inflammatory disorders and various cancers, but it has additionally been reported that treatment targeting NF-κB also shows a radioprotective effect.
IMD-0354 is an IKKβ inhibitor that blocks IκBα phosphorylation in the NF-κB pathway.
This compound is known to exert anti-inflammatory and antitumor effects, but its radioprotective effects are unclear.
Therefore, in the present study, we examined whether or not IMD-0354 has a mitigative effect on radiation-induced damages in mice.
IMD-0354 was dissolved in soybean oil and subcutaneously administered to C57BL/6J Jcl mice for 3 consecutive days after 7 Gy of whole-body X-irradiation.
The survival rate on day 30 and the NF-κB p65 and IκBα in bone marrow and spleen cells based on flow cytometry were assessed.
IMD-0354 administration significantly suppressed the lethality induced by whole-body X-irradiation, and the survival rate increased by 83%.
The NF-κB p65 and IκBα in bone marrow and spleen cells were significantly lower in IMD-0354-treated mice than in irradiated mice, suggesting that the IKKβ inhibitor IMD-0354 exerts a radiomitigative effect by suppressing the NF-κB.
American Psychological Association (APA)
Waga, Kengo& Yamaguchi, Masaru& Miura, Shuta& Nishida, Teruki& Itai, Akiko& Nakanishi, Reiko…[et al.]. 2019. IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1204094
Modern Language Association (MLA)
Waga, Kengo…[et al.]. IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1204094
American Medical Association (AMA)
Waga, Kengo& Yamaguchi, Masaru& Miura, Shuta& Nishida, Teruki& Itai, Akiko& Nakanishi, Reiko…[et al.]. IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1204094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204094