Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model
Joint Authors
Akinnuga, Akinjide Moses
Siboto, Angezwa
Khumalo, Bongiwe
Sibiya, Ntethelelo Hopewell
Ngubane, Phikelelani
Khathi, Andile
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recently, studies have shown that renal dysfunction is associated not only with overt diabetes but also with the preceding stage known as prediabetes.
Diet and pharmacological interventions are the therapeutic approaches to managing prediabetes, but the compliance in combining the two interventions is low.
Hence, the efficacy of pharmacological intervention is reduced without diet modification.
In our previous study, we established that bredemolic acid (BA) ameliorated glucose homeostasis via increased GLUT 4 expression in the skeletal muscle of prediabetic rats in the absence of diet intervention.
However, the effects of bredemolic acid on renal function in prediabetic condition are unknown.
Therefore, this study was aimed at investigating the ameliorative effects of bredemolic acid on renal dysfunction in a diet-induced prediabetic rat model.
Thirty-six Sprague-Dawley male rats (150–180 g) were divided into two groups: the nonprediabetic (n=6) and prediabetic (n=30) groups which were fed normal diet (ND) and high-fat high-carbohydrate (HFHC) diet, respectively, for 20 weeks.
After the 20th week, the prediabetic groups were subdivided into prediabetic control (PD) and 4 other prediabetic groups which were treated with either BA (80 mg/kg) or metformin (MET, 500 mg/kg) for further 12 weeks (21st to 32nd).
Plasma, urine, and kidney samples were collected for biochemical analysis.
The untreated prediabetic (PD) rats presented increased fluid intake and urine output; increased creatinine, urea, and uric acid plasma concentrations; albuminuria; proteinuria; sodium retention; potassium loss; increased aldosterone and kidney injury molecule (KIM-1) concentration; and increased urinary podocin mRNA expression.
However, BA administration attenuated the renal markers and oxidative stress and decreased the urinary podocin mRNA expression.
In conclusion, BA administration, regardless of diet modification, attenuates renal dysfunction in an experimentally induced prediabetic state.
American Psychological Association (APA)
Akinnuga, Akinjide Moses& Siboto, Angezwa& Khumalo, Bongiwe& Sibiya, Ntethelelo Hopewell& Ngubane, Phikelelani& Khathi, Andile. 2020. Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204102
Modern Language Association (MLA)
Akinnuga, Akinjide Moses…[et al.]. Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204102
American Medical Association (AMA)
Akinnuga, Akinjide Moses& Siboto, Angezwa& Khumalo, Bongiwe& Sibiya, Ntethelelo Hopewell& Ngubane, Phikelelani& Khathi, Andile. Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204102