Characterization of CD4+ T Cell Subsets in Patients with Abdominal Aortic Aneurysms

Joint Authors

Milani Altemani, Albina Messias de Almeida
Téo, Fábio Haach
de Oliveira, Rômulo Tadeu Dias
Villarejos, Liana
Mamoni, Ronei Luciano
Menezes, Fabio Husemann
Blotta, Maria Heloisa Souza Lima

Source

Mediators of Inflammation

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-12-27

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Background.

The mediators produced by CD4+ T lymphocytes are involved in the pathogenesis of aneurysmal lesions in abdominal aortic aneurysm (AAA) patients.

The aim of this study was to identify and characterize the CD4+ T cell subsets involved in human AAA.

Methods.

The CD4+ T cell subsets in 30 human aneurysmal lesions were determined using flow cytometry (FC) and immunohistochemistry (IHC).

The peripheral blood mononuclear cells (PBMCs) from patients with AAA were also analyzed by FC and compared with control subjects.

Results.

Human aneurysmal lesions contained IFN-γ, IL-12p35, IL-4, IL-23p19, IL-17R, and IL-22 positive cells.

PBMCs from AAA patients had higher expression levels of IFN-γ, TNF-α, IL-4, and IL-22 when compared to controls.

Conclusions.

Our results show the presence of TH1, TH2, TH17, and TH22 subsets in aneurysmal lesions of AAA patients and suggest that these cells may be mainly activated in situ, where they can induce tissue degradation and contribute to the pathogenesis of AAA.

American Psychological Association (APA)

Téo, Fábio Haach& de Oliveira, Rômulo Tadeu Dias& Villarejos, Liana& Mamoni, Ronei Luciano& Milani Altemani, Albina Messias de Almeida& Menezes, Fabio Husemann…[et al.]. 2018. Characterization of CD4+ T Cell Subsets in Patients with Abdominal Aortic Aneurysms. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1204108

Modern Language Association (MLA)

Téo, Fábio Haach…[et al.]. Characterization of CD4+ T Cell Subsets in Patients with Abdominal Aortic Aneurysms. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1204108

American Medical Association (AMA)

Téo, Fábio Haach& de Oliveira, Rômulo Tadeu Dias& Villarejos, Liana& Mamoni, Ronei Luciano& Milani Altemani, Albina Messias de Almeida& Menezes, Fabio Husemann…[et al.]. Characterization of CD4+ T Cell Subsets in Patients with Abdominal Aortic Aneurysms. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1204108

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1204108