Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome
Joint Authors
Wattanathorn, Jintanaporn
Kawvised, Supannika
Thukham-mee, Wipawee
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-28
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Currently, the therapeutic strategy against metabolic syndrome and its complications is required due to the increasing prevalence and its impact.
Due to the benefits of both mulberry fruit extract and encapsulation technology, we hypothesized that encapsulated mulberry fruit extract (MME) could improve metabolic parameters and its complication risk in postmenopausal metabolic syndrome.
To test this hypothesis, female Wistar rats were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and high-carbohydrate high-fat (HCHF) diet.
Then, they were orally given MME at doses of 10, 50, and 250 mg/kg BW for 8 weeks and the parameters, such as percentage of body weight gain, total cholesterol, triglycerides, HDL-C, LDL-C, atherogenic index, fasting blood glucose, plasma glucose area under the curve, serum angiotensin-converting enzyme (ACE), oxidative stress status, histology, and protein expression of PPAR-γ, TNF-α, and NF-κB in adipose tissues were determined.
MME improved body weight gain, adiposity index, glucose intolerance, lipid profiles, atherogenic index, ACE, oxidative stress status, and protein expression of TNF-α and NF-κB.
Moreover, MME attenuated adipocyte hypertrophy and enhanced PPAR-γ expression.
Taken altogether, MME decreased metabolic syndrome and its complication via the increased PPAR-γ expression.
Therefore, MME is the potential candidate for improving metabolic syndrome and its related complications.
However, further research in clinical trial is still necessary.
American Psychological Association (APA)
Wattanathorn, Jintanaporn& Kawvised, Supannika& Thukham-mee, Wipawee. 2019. Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1204109
Modern Language Association (MLA)
Wattanathorn, Jintanaporn…[et al.]. Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-23.
https://search.emarefa.net/detail/BIM-1204109
American Medical Association (AMA)
Wattanathorn, Jintanaporn& Kawvised, Supannika& Thukham-mee, Wipawee. Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1204109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204109