Understanding of ROS-Inducing Strategy in Anticancer Therapy
Joint Authors
Kim, Su Ji
Kim, Hyun Soo
Seo, Youngrok
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Redox homeostasis is essential for the maintenance of diverse cellular processes.
Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells as a result of hypermetabolism, but the redox balance is maintained in cancer cells due to their marked antioxidant capacity.
Recently, anticancer therapies that induce oxidative stress by increasing ROS and/or inhibiting antioxidant processes have received significant attention.
The acceleration of accumulative ROS disrupts redox homeostasis and causes severe damage in cancer cells.
In this review, we describe ROS-inducing cancer therapy and the anticancer mechanism employed by prooxidative agents.
To understand the comprehensive biological response to certain prooxidative anticancer drugs such as 2-methoxyestradiol, buthionine sulfoximine, cisplatin, doxorubicin, imexon, and motexafin gadolinium, we propose and visualize the drug-gene, drug-cell process, and drug-disease interactions involved in oxidative stress induction and antioxidant process inhibition as well as specific side effects of these drugs using pathway analysis with a big data-based text-mining approach.
Our review will be helpful to improve the therapeutic effects of anticancer drugs by providing information about biological changes that occur in response to prooxidants.
For future directions, there is still a need for pharmacogenomic studies on prooxidative agents as well as the molecular mechanisms underlying the effects of the prooxidants and/or antioxidant-inhibitor agents for effective anticancer therapy through selective killing of cancer cells.
American Psychological Association (APA)
Kim, Su Ji& Kim, Hyun Soo& Seo, Youngrok. 2019. Understanding of ROS-Inducing Strategy in Anticancer Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1204114
Modern Language Association (MLA)
Kim, Su Ji…[et al.]. Understanding of ROS-Inducing Strategy in Anticancer Therapy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1204114
American Medical Association (AMA)
Kim, Su Ji& Kim, Hyun Soo& Seo, Youngrok. Understanding of ROS-Inducing Strategy in Anticancer Therapy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1204114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204114