The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases
Joint Authors
Morandi, Fabio
Rizzo, R.
Horenstein, Alberto L.
Malavasi, Fabio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells.
ADO is produced from ATP through the enzymatic activities of CD39 and CD73.
Alternatively, ADO can be generated starting from NAD+, which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73.
The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings.
This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models.
The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases.
American Psychological Association (APA)
Morandi, Fabio& Horenstein, Alberto L.& Rizzo, R.& Malavasi, Fabio. 2018. The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204115
Modern Language Association (MLA)
Morandi, Fabio…[et al.]. The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1204115
American Medical Association (AMA)
Morandi, Fabio& Horenstein, Alberto L.& Rizzo, R.& Malavasi, Fabio. The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204115
