![](/images/graphics-bg.png)
Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
Joint Authors
Marzetti, Emanuele
Landi, Francesco
Calvani, Riccardo
Picca, Anna
Sisto, Alex
Fanelli, Francesca
Mulè, Giuseppina
Pesce, Vito
Pantanelli, Cecilia
Bernabei, Roberto
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Advanced age is characterized by several changes, one of which is the impairment of the homeostasis of intestinal microbiota.
These alterations critically influence host health and have been associated with morbidity and mortality in older adults.
“Inflammaging,” an age-related chronic inflammatory process, is a common trait of several conditions, including sarcopenia.
Interestingly, imbalanced intestinal microbial community has been suggested to contribute to inflammaging.
Changes in gut microbiota accompanying sarcopenia may be attenuated by supplementation with pre- and probiotics.
Although muscle aging has been increasingly recognized as a biomarker of aging, the pathophysiology of sarcopenia is to date only partially appreciated.
Due to its development in the context of the age-related inflammatory milieu, several studies favor the hypothesis of a tight connection between sarcopenia and inflammaging.
However, conclusive evidence describing the signaling pathways involved has not yet been produced.
Here, we review the current knowledge of the changes in intestinal microbiota that occur in advanced age with a special emphasis on findings supporting the idea of a modulation of muscle physiology through alterations in gut microbial composition and activity.
American Psychological Association (APA)
Picca, Anna& Fanelli, Francesca& Calvani, Riccardo& Mulè, Giuseppina& Pesce, Vito& Sisto, Alex…[et al.]. 2018. Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1204118
Modern Language Association (MLA)
Picca, Anna…[et al.]. Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia. Mediators of Inflammation No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1204118
American Medical Association (AMA)
Picca, Anna& Fanelli, Francesca& Calvani, Riccardo& Mulè, Giuseppina& Pesce, Vito& Sisto, Alex…[et al.]. Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1204118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204118