Selected Biomarkers Correlate with the Origin and Severity of Sepsis
Joint Authors
Davidová, Alžběta
Dzupova, Olga
Bartáková, Eva
Máca, Jan
Růžková, Michaela
Beneš, Jiří
Herwald, Heiko
Beran, Ondřej
Holub, Michal
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The microbial etiology and source of sepsis influence the inflammatory response.
Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization.
The etiology was established in 56 out of a total of 62 patients enrolled in the study.
Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n=10) and infective endocarditis (IE; n=11) compared to those with bacterial meningitis (BM; n=18).
Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections.
Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score.
In addition, HBP levels were significantly higher in patients with IE than in those with BM.
Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.
American Psychological Association (APA)
Holub, Michal& Dzupova, Olga& Růžková, Michaela& Davidová, Alžběta& Bartáková, Eva& Máca, Jan…[et al.]. 2018. Selected Biomarkers Correlate with the Origin and Severity of Sepsis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204121
Modern Language Association (MLA)
Holub, Michal…[et al.]. Selected Biomarkers Correlate with the Origin and Severity of Sepsis. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204121
American Medical Association (AMA)
Holub, Michal& Dzupova, Olga& Růžková, Michaela& Davidová, Alžběta& Bartáková, Eva& Máca, Jan…[et al.]. Selected Biomarkers Correlate with the Origin and Severity of Sepsis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204121