Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation
Joint Authors
Zhao, Yajun
Chai, Nannan
Zhang, Hao
Li, Lingxu
Yu, Xue
Liu, Yan
Lin, Yan
Wang, Lina
Yan, Jiamin
Nikolaevna, Sazonova Elena
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Intrauterine hypoxia (IUH) is a common intrauterine dysplasia that can cause programming of the offspring cardiovascular system.
In this study, we hypothesized that placental treatment with spermidine (SPD) can prevent heart injury in neonatal offspring exposed to IUH.
Pregnant rats were exposed to 21% O2 or 10% O2 (hypoxia) for 7 days prior to term or were exposed to hypoxia and intraperitoneally administered SPD or SPD+difluromethylornithine (DFMO) on gestational days 15-21.
Seven-day-old offspring were then sacrificed to assess several parameters.
Our results demonstrated that IUH led to decreased myocardial ornithine decarboxylase (ODC) and increased spermidine/spermine N1-acetyltransferase (SSAT) expression in the offspring.
IUH also resulted in decreased offspring body weight, heart weight, cardiomyocyte proliferation, and antioxidant capacity and increased cardiomyocyte apoptosis and fibrosis.
Furthermore, IUH caused mitochondrial structure abnormality, dysfunction, and decreased biogenesis and led to a fission/fusion imbalance in offspring hearts.
In vitro, hypoxia induced mitochondrial ROS accumulation, decreased membrane potential, and increased fragmentation.
Notably, all hypoxia-induced changes analyzed in this study were prevented by SPD.
Thus, in utero SPD treatment is a potential strategy for preventing IUH-induced neonatal cardiac injury.
American Psychological Association (APA)
Chai, Nannan& Zhang, Hao& Li, Lingxu& Yu, Xue& Liu, Yan& Lin, Yan…[et al.]. 2019. Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1204124
Modern Language Association (MLA)
Chai, Nannan…[et al.]. Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1204124
American Medical Association (AMA)
Chai, Nannan& Zhang, Hao& Li, Lingxu& Yu, Xue& Liu, Yan& Lin, Yan…[et al.]. Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1204124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204124