Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice
Joint Authors
Yi, Xuejie
Tang, Donghui
Cao, Shicheng
Li, Tao
Gao, Haining
Ma, Tie
Yao, Tingting
Li, Jing
Chang, Bo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study is aimed at investigating the effect of different exercise loads on the reproductive function of obese male mice and the underlying mechanisms.
Male mice with high-fat diet-induced obesity were divided into obesity control (OC), obesity moderate-load exercise (OME), and obesity high-load exercise (OHE) groups.
The OME and OHE groups were subjected to swimming exercise 5 days per week over a duration of 8 weeks, with the exercise load progressively increased to 2 h per day in the OME group and 2 h twice per day in the OHE group.
In the OC group mice without exercise regimen, we observed a decrease in mRNA expression of antioxidant enzymes, increase in free radical products, upregulation of mRNA and protein expression of nuclear factor-κB and proinflammatory cytokines, inhibition of mRNA and protein expression of testosterone synthases, decrease in the serum testosterone level and sperm quality, and increase in sperm apoptosis.
Although both moderate-load exercise and high-load exercise reduced body fat, only moderate-load exercise effectively alleviated obesity-induced oxidative stress, downregulated the expression of nuclear factor-κB and proinflammatory cytokines, and reversed the decrease in mRNA and protein expression of testosterone synthases, serum testosterone level, and sperm quality.
These changes were not observed in the OHE group mice.
Obesity-induced testicular oxidative stress and inflammatory response decreased testosterone synthesis and sperm quality.
Moderate-load exercise alleviated the negative effect of obesity on male reproductive function by decreasing testicular oxidative stress and inflammatory responses.
Although high-load exercise effectively reduced body fat, its effects on alleviating oxidative stress and improving male reproductive function were limited.
American Psychological Association (APA)
Yi, Xuejie& Tang, Donghui& Cao, Shicheng& Li, Tao& Gao, Haining& Ma, Tie…[et al.]. 2020. Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204137
Modern Language Association (MLA)
Yi, Xuejie…[et al.]. Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204137
American Medical Association (AMA)
Yi, Xuejie& Tang, Donghui& Cao, Shicheng& Li, Tao& Gao, Haining& Ma, Tie…[et al.]. Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204137