Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress
Joint Authors
Lin, Mao
Zhong, Julia Li
Nisar, Muhammad Farrukh
Chen, ShiDa
Wang, XiaoYu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-21
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Ultraviolet (UV) irradiation can be considered as a double-edged sword: not only is it a crucial environmental factor that can cause skin-related disorders but it can also be used for phototherapy of skin diseases.
Inducible heme oxygenase-1 (HO-1) in response to a variety of stimuli, including UV exposure, is vital to maintain cell homeostasis.
Heme oxygenase-2 (HO-2), another member of the heme oxygenase family, is constitutively expressed.
In this review, we discuss how heme oxygenase (HO), a vital rate-limiting enzyme, participates in heme catabolism and cytoprotection.
Phylogenetic analysis showed that there may exist a functional differentiation between HO-1 and HO-2 during evolution.
Furthermore, depending on functions in immunomodulation and antioxidation, HO-1 participates in disease progression, especially in pathogenesis of skin diseases, such as vitiligo and psoriasis.
To further investigate the particular role of HO-1 in diseases, we summarized the profile of the HO enzyme system and its related signaling pathways, such as Nrf2 and endoplasmic reticulum crucial signaling, both known to regulate HO-1 expression.
Furthermore, we report on a C-terminal truncation of HO-1, which is generally considered as a signal molecule.
Also, a newly identified alternative splice isoform of HO-1 not only provides us a novel perspective on comprehensive HO-1 alternative splicing but also offers us a basis to clarify the relationship between HO-1 transcripts and oxidative diseases.
To conclude, the HO system is not only involved in heme catabolism but also involved in biological processes related to the pathogenesis of certain diseases, even though the mechanism of disease progression still remains sketchy.
Further understanding the role of the HO system and its relationship to UV is helpful for revealing the HO-related signaling networks and the pathogenesis of many diseases.
American Psychological Association (APA)
Chen, ShiDa& Wang, XiaoYu& Nisar, Muhammad Farrukh& Lin, Mao& Zhong, Julia Li. 2019. Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1204141
Modern Language Association (MLA)
Chen, ShiDa…[et al.]. Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1204141
American Medical Association (AMA)
Chen, ShiDa& Wang, XiaoYu& Nisar, Muhammad Farrukh& Lin, Mao& Zhong, Julia Li. Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1204141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204141