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Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS
Joint Authors
von Bernhardi, Rommy
Beltrán-Castillo, Sebastián
Eugenín, Jaime
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A mild chronic inflammatory state, like that observed in aged individuals, affects microglial function, inducing a dysfunctional phenotype that potentiates neuroinflammation and cytotoxicity instead of neuroprotection in response to additional challenges.
Given that inflammatory activation of microglia promotes increased release of D-serine, we postulate that age-dependent inflammatory brain environment leads to microglia-mediated changes on the D-serine-regulated glutamatergic transmission.
Furthermore, D-serine dysregulation, in addition to affecting synaptogenesis and synaptic plasticity, appears also to potentiate NMDAR-dependent excitotoxicity, promoting neurodegeneration and cognitive impairment.
D-serine dysregulation promoted by microglia could have a role in age-related cognitive impairment and in the induction and progression of neurodegenerative processes like Alzheimer’s disease.
American Psychological Association (APA)
Beltrán-Castillo, Sebastián& Eugenín, Jaime& von Bernhardi, Rommy. 2018. Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204142
Modern Language Association (MLA)
Beltrán-Castillo, Sebastián…[et al.]. Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204142
American Medical Association (AMA)
Beltrán-Castillo, Sebastián& Eugenín, Jaime& von Bernhardi, Rommy. Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204142