The Association of Paraoxonase-1 Polymorphism with Carotid Artery Stenosis among Elderly Chinese Population
Joint Authors
Zhou, Zhiming
Sun, Jianyun
Wang, Long
Yang, Qian
Zhou, Taofeng
Ding, Xianhui
Yang, Ke
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Elderly population is in high risk of carotid atherosclerosis and artery stenosis (CAS).
It has been proved that PON1 polymorphism is associated with low-density lipoprotein (LDL) oxidation, which plays an important role in artery atherosclerosis.
CAS is an important cause of ischemic stroke.
This study is aimed at investigating the association of PON1 (rs662) polymorphism with the risk of CAS among elderly Chinese population.
Consecutive elderly patients with CAS were enrolled into the study.
Genotyping for PON1 (rs662) polymorphism was performed on all participants.
There were 310 CAS patients in this study, with 88 symptomatic CAS and 222 asymptomatic CAS.
G allele had a frequency of 59.66% in symptomatic CAS (sCAS); and A allele had an incidence of 36.93% in asymptomatic CAS (aCAS) (P<0.05).
In all CAS patients with and without symptom, no associations were found in any genotype comparison.
However, among aCAS subjects, based on GA phenotype, the odds ratio (OR) of the mutant GG with stenosis severity was 0.20 (P=0.01).
The OR of GG+GA mutation was 0.28 for moderate/severe severity, compared with GA type (P=0.03).
This study indicates that PON1 (rs662) polymorphism is not associated with the presence of symptom among CAS patients.
Moreover, PON1 (rs662) polymorphism correlates with stenosis severity among aCAS.
American Psychological Association (APA)
Sun, Jianyun& Wang, Long& Yang, Qian& Zhou, Taofeng& Ding, Xianhui& Yang, Ke…[et al.]. 2020. The Association of Paraoxonase-1 Polymorphism with Carotid Artery Stenosis among Elderly Chinese Population. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1204143
Modern Language Association (MLA)
Sun, Jianyun…[et al.]. The Association of Paraoxonase-1 Polymorphism with Carotid Artery Stenosis among Elderly Chinese Population. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1204143
American Medical Association (AMA)
Sun, Jianyun& Wang, Long& Yang, Qian& Zhou, Taofeng& Ding, Xianhui& Yang, Ke…[et al.]. The Association of Paraoxonase-1 Polymorphism with Carotid Artery Stenosis among Elderly Chinese Population. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1204143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204143