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Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation
Joint Authors
Cardona-Muñoz, Ernesto German
Rodríguez-Carrizalez, Adolfo Daniel
Arévalo Simental, Diana E.
Cecilia, Olvera-Montaño
José Alberto, Castellanos-González
Ana Karen, López-Contreras
Ricardo Raúl, Robles-Rivera
Flores-Martin, Raúl Alonso
Roman-Pintos, Luis Miguel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-11
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Diabetes mellitus (DM) is a progressive disease induced by a sustained state of chronic hyperglycemia that can lead to several complications targeting highly metabolic cells.
Diabetic retinopathy (DR) is a multifactorial microvascular complication of DM, with high prevalence, which can ultimately lead to visual impairment.
The genesis of DR involves a complex variety of pathways such as oxidative stress, inflammation, apoptosis, neurodegeneration, angiogenesis, lipid peroxidation, and endoplasmic reticulum (ER) stress, each possessing potential therapeutic biomarkers.
A specific treatment has yet to be developed for early stages of DR since no management is given other than glycemic control until the proliferative stage develops, offering a poor visual prognosis to the patient.
In this narrative review article, we evaluate different dietary regimens, such as the Mediterranean diet, Dietary Pattern to Stop Hypertension (DASH) and their functional foods, and low-calorie diets (LCDs).
Nutraceuticals have also been assessed in DR on account of their antioxidant, anti-inflammatory, and antiangiogenic properties, which may have an important impact on the physiopathology of DR.
These nutraceuticals have shown to lower reactive oxygen species (ROS), important inflammatory factors, cytokines, and endothelial damage biomarkers either as monotherapies or combined therapies or concomitantly with established diabetes management or nonconventional adjuvant drugs like topical nonsteroidal anti-inflammatory drugs (NSAIDs).
American Psychological Association (APA)
Ricardo Raúl, Robles-Rivera& José Alberto, Castellanos-González& Cecilia, Olvera-Montaño& Flores-Martin, Raúl Alonso& Ana Karen, López-Contreras& Arévalo Simental, Diana E.…[et al.]. 2020. Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1204147
Modern Language Association (MLA)
Ricardo Raúl, Robles-Rivera…[et al.]. Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1204147
American Medical Association (AMA)
Ricardo Raúl, Robles-Rivera& José Alberto, Castellanos-González& Cecilia, Olvera-Montaño& Flores-Martin, Raúl Alonso& Ana Karen, López-Contreras& Arévalo Simental, Diana E.…[et al.]. Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1204147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204147