Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38JNK Pathway and Peripheral Obliterans in Rats
Joint Authors
Sun, Li
Xu, Jin-Wen
Guo, H. N.
Ling, Shuang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Inflammation is one of the most important pathogeneses of thromboangiitis obliterans (TAO).
The NLRP3 inflammasome plays a vital role in the body’s immune response and disease development.
It can be activated by numerous types of pathogens or danger signals.
As the core of the inflammatory response, the NLRP3 inflammasome may provide a new target for the treatment of various inflammatory diseases.
Levistilide A (LA) is a phthalide dimer isolated from umbelliferous plants.
Its pharmacological effect is largely unknown.
This study revealed the effects of LA on endothelial cell activation, NLRP3, IL-1β, TNF-α, IL-32, and CCL-2, VCAM-1, MCP-1, and the spleen tyrosine kinase (Syk)--p38/JNK signaling axis and its effect on vasculitis in rats.
Results.
LA inhibited endothelial activation and the expression of IL-1β, TNF-α, IL-32, CCL-2, VCAM-1, and MCP-1.
LA directly obstructed Syk phosphorylation and activity in a dose-dependent manner, inhibited the activity of p38 and JNK, and reduced the expression of NLRP3 in human umbilical vein endothelial cells and vascular tissue of rats with vasculitis.
Conclusion.
LA suppressed NLRP3 gene expression by blocking the Syk--p38/JNK pathway and reduced damage to the rats’ limbs in the thromboangiitis obliterans model.
American Psychological Association (APA)
Guo, H. N.& Sun, Li& Ling, Shuang& Xu, Jin-Wen. 2018. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38JNK Pathway and Peripheral Obliterans in Rats. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204161
Modern Language Association (MLA)
Guo, H. N.…[et al.]. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38JNK Pathway and Peripheral Obliterans in Rats. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204161
American Medical Association (AMA)
Guo, H. N.& Sun, Li& Ling, Shuang& Xu, Jin-Wen. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38JNK Pathway and Peripheral Obliterans in Rats. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204161