Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
Joint Authors
López-Collazo, Eduardo
Toledano, Víctor
Varela-Serrano, Aníbal
Cubillos-Zapata, Carolina
Hernández-Jiménez, Enrique
Avendaño-Ortiz, José
Fernández-Navarro, Isabel
Casitas, Raquel
Aguirre, Luis A.
Río, Francisco García
Carpio, Carlos
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep.
Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors.
Both OSA and healthy monocytes have been found to show enhanced HIF1α expression under IH.
Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1α-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF).
Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1α secretion.
Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context.
American Psychological Association (APA)
Cubillos-Zapata, Carolina& Hernández-Jiménez, Enrique& Avendaño-Ortiz, José& Toledano, Víctor& Varela-Serrano, Aníbal& Fernández-Navarro, Isabel…[et al.]. 2018. Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1204168
Modern Language Association (MLA)
Cubillos-Zapata, Carolina…[et al.]. Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1204168
American Medical Association (AMA)
Cubillos-Zapata, Carolina& Hernández-Jiménez, Enrique& Avendaño-Ortiz, José& Toledano, Víctor& Varela-Serrano, Aníbal& Fernández-Navarro, Isabel…[et al.]. Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1204168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204168