Apatinib, a Novel Tyrosine Kinase Inhibitor, Promotes ROS-Dependent Apoptosis and Autophagy via the Nrf2HO-1 Pathway in Ovarian Cancer Cells
Joint Authors
Sun, Xiaodan
Li, Ji
Li, Yizhuo
Wang, Shouhan
Li, Qingchang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-14
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Apatinib, a new-generation oral tyrosine kinase inhibitor targeting the vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathway, shows favorable therapeutic effects in various malignant tumors.
However, its effect on ovarian cancer has not yet been characterized.
Here, we demonstrated that apatinib inhibited ovarian cancer cell growth and migration in a concentration-dependent manner.
Further, we found that apatinib could directly act on tumor cells and promote ROS-dependent apoptosis and autophagy.
Mechanistically, we showed that apatinib suppressed glutathione to generate ROS via the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and maintained an antitumor effect at a low level of VEGFR2 in ovarian cancer, suggesting that combination of apatinib with Nrf2 inhibitor may be a promising therapy strategy for patients with ovarian cancer.
American Psychological Association (APA)
Sun, Xiaodan& Li, Ji& Li, Yizhuo& Wang, Shouhan& Li, Qingchang. 2020. Apatinib, a Novel Tyrosine Kinase Inhibitor, Promotes ROS-Dependent Apoptosis and Autophagy via the Nrf2HO-1 Pathway in Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204169
Modern Language Association (MLA)
Sun, Xiaodan…[et al.]. Apatinib, a Novel Tyrosine Kinase Inhibitor, Promotes ROS-Dependent Apoptosis and Autophagy via the Nrf2HO-1 Pathway in Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1204169
American Medical Association (AMA)
Sun, Xiaodan& Li, Ji& Li, Yizhuo& Wang, Shouhan& Li, Qingchang. Apatinib, a Novel Tyrosine Kinase Inhibitor, Promotes ROS-Dependent Apoptosis and Autophagy via the Nrf2HO-1 Pathway in Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204169