Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial
Joint Authors
Molinari, Nicolas
Maury, Jonathan
Gouzi, Farés
Heraud, Nelly
Pomiès, Pascal
Laoudj-Chenivesse, Dalila
Préfaut, Christian
Hayot, Maurice
Cristol, Jean-Paul
Bertet, Héléna
Ayoub, Bronia
Blaquière, Marine
Bughin, François
De Rigal, Philippe
Poulain, Magali
Pincemail, Joël
Mercier, Jacques
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD) is not fully reversed by exercise training.
Antioxidants are critical for muscle homeostasis and adaptation to training.
However, COPD patients experience antioxidant deficits that worsen after training and might impact their muscle response to training.
Nutritional antioxidant supplementation in combination with pulmonary rehabilitation (PR) would further improve muscle function, oxidative stress, and PR outcomes in COPD patients.
Methods.
Sixty-four COPD patients admitted to inpatient PR were randomized to receive 28 days of oral antioxidant supplementation targeting the previously observed deficits (PR antioxidant group; α-tocopherol: 30 mg/day, ascorbate: 180 mg/day, zinc gluconate: 15 mg/day, selenomethionine: 50 μg/day) or placebo (PR placebo group).
PR consisted of 24 sessions of moderate-intensity exercise training.
Changes in muscle endurance (primary outcome), oxidative stress, and PR outcomes were assessed.
Results.
Eighty-one percent of the patients (FEV1=58.9±20.0%pred) showed at least one nutritional antioxidant deficit.
Training improved muscle endurance in the PR placebo group (+37.4±45.1%, p<0.001), without additional increase in the PR antioxidant group (-6.6±11.3%; p=0.56).
Nevertheless, supplementation increased the α-tocopherol/γ-tocopherol ratio and selenium (+58±20%, p<0.001, and +16±5%, p<0.01, respectively), muscle strength (+11±3%, p<0.001), and serum total proteins (+7±2%, p<0.001), and it tended to increase the type I fiber proportion (+32±17%, p=0.07).
The prevalence of muscle weakness decreased in the PR antioxidant group only, from 30.0 to 10.7% (p<0.05).
Conclusions.
While the primary outcome was not significantly improved, COPD patients demonstrate significant improvements of secondary outcomes (muscle strength and other training-refractory outcomes), suggesting a potential “add-on” effect of the nutritional antioxidant supplementation (vitamins C and E, zinc, and selenium) during PR.
This trial is registered with NCT01942889.
American Psychological Association (APA)
Gouzi, Farés& Maury, Jonathan& Heraud, Nelly& Molinari, Nicolas& Bertet, Héléna& Ayoub, Bronia…[et al.]. 2019. Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204186
Modern Language Association (MLA)
Gouzi, Farés…[et al.]. Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204186
American Medical Association (AMA)
Gouzi, Farés& Maury, Jonathan& Heraud, Nelly& Molinari, Nicolas& Bertet, Héléna& Ayoub, Bronia…[et al.]. Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204186