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Regulatory T Lymphocytes in Periodontitis: A Translational View
Joint Authors
Vernal, Rolando
Alvarez, Carla
Rojas, Carolina
Rojas, Leticia
Cafferata, Emilio A.
Monasterio, Gustavo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease.
The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage.
Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy.
In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the ex vivo and in vivo manipulation of the Treg compartment.
Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies.
Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.
American Psychological Association (APA)
Alvarez, Carla& Rojas, Carolina& Rojas, Leticia& Cafferata, Emilio A.& Monasterio, Gustavo& Vernal, Rolando. 2018. Regulatory T Lymphocytes in Periodontitis: A Translational View. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204199
Modern Language Association (MLA)
Alvarez, Carla…[et al.]. Regulatory T Lymphocytes in Periodontitis: A Translational View. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1204199
American Medical Association (AMA)
Alvarez, Carla& Rojas, Carolina& Rojas, Leticia& Cafferata, Emilio A.& Monasterio, Gustavo& Vernal, Rolando. Regulatory T Lymphocytes in Periodontitis: A Translational View. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204199