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Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia
Joint Authors
Cui, Li
Xu, Xiaoxiang
Wei, Yingjia
Shah, Mian Khaqan
Wang, Xiaoyu
Lin, Junting
Wan, Peng
Yin, Qingqiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Active peptides have good effectiveness in controlling or preventing many diseases.
Compound active peptides (CAP) obtained from animal, plant, and sea food proteins were used in this study to explore their effects on antioxidation, anti-inflammation, and antihyperglycemia in vitro and in vivo.
The results demonstrated that 10 μg/mL CAP could increase cell viability (P<0.05) and decrease reactive oxygen species (ROS) levels and cell apoptosis (P<0.05) when WRL68 cells were induced by H2O2 for 6 h.
Moreover, incubation with 20 μg/mL CAP for 6 h significantly increased cell viability and Bcl-2 expression level (P<0.05) and decreased expression levels of IL-6, IL-8, TNF-α, Bax, and Caspase 3 and the ratio of Bax/Bcl-2 (P<0.05) when swine jejunal epithelial cells (IPEC-J2) were induced by deoxynivalenol (DON).
In addition, adding CAP individually or combined with Liuweidihuang pills (LDP, Chinese medicine) and low-dose glibenclamide could lower blood glucose levels in alloxan-induced hyperglycemic model mice.
These results suggested that CAP was probably a beneficial ingredient for alleviating H2O2-induced oxidative stress and DON-induced cell inflammation and apoptosis and preventing hyperglycemia.
American Psychological Association (APA)
Xu, Xiaoxiang& Wei, Yingjia& Shah, Mian Khaqan& Wang, Xiaoyu& Lin, Junting& Wan, Peng…[et al.]. 2020. Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204200
Modern Language Association (MLA)
Xu, Xiaoxiang…[et al.]. Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204200
American Medical Association (AMA)
Xu, Xiaoxiang& Wei, Yingjia& Shah, Mian Khaqan& Wang, Xiaoyu& Lin, Junting& Wan, Peng…[et al.]. Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204200