The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases
Joint Authors
Zhang, Jianmin
Wang, Yali
Gao, Qiannan
Lin, Xu
Fang, Yuanjian
Wang, Xiaoyu
Zhou, Yunxiang
Ping, Dongnan
Shao, Anwen
Wu, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease are aging-associated diseases with irreversible damage of brain tissue.
Oxidative stress is commonly detected in neurodegenerative diseases and related to neuronal injury and pathological progress.
Exosome, one of the extracellular vesicles, is demonstrated to carry microRNAs (miRNAs) and build up a cell-cell communication in neurons.
Recent research has found that exosomal miRNAs regulate the activity of multiple physiological pathways, including the oxidative stress response, in neurodegenerative diseases.
Here, we review the role of exosomal miRNAs and oxidative stress in neurodegenerative diseases.
Firstly, we explore the relationship between oxidative stress and neurodegenerative diseases.
Secondly, we introduce the characteristics of exosomes and roles of exosome-related miRNAs.
Thirdly, we summarized the crosstalk between exosomal miRNAs and oxidative stress in neurodegenerative diseases.
Fourthly, we discuss the potential of exosomes to be a biomarker in neurodegenerative diseases.
Finally, we summarize the advantages of exosome-based delivery and present situation of research on exosome-based delivery of therapeutic miRNA.
Our work is aimed at probing and reinforcing the recognition of the pathomechanism of neurodegenerative diseases and providing the basis for novel strategies of clinical diagnosis and treatment.
American Psychological Association (APA)
Wang, Xiaoyu& Zhou, Yunxiang& Gao, Qiannan& Ping, Dongnan& Wang, Yali& Wu, Wei…[et al.]. 2020. The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204215
Modern Language Association (MLA)
Wang, Xiaoyu…[et al.]. The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1204215
American Medical Association (AMA)
Wang, Xiaoyu& Zhou, Yunxiang& Gao, Qiannan& Ping, Dongnan& Wang, Yali& Wu, Wei…[et al.]. The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204215