Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38JNK Signaling Pathways
Joint Authors
Wang, Kai
You, Meng-Meng
Chen, Yi-Fan
Pan, Yong-Ming
Liu, Yi-Chen
Tu, Jue
Hu, Fuliang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Royal jelly (RJ), a hive product with versatile pharmacological activities, has been used as a traditional functional food to prevent or treat inflammatory diseases.
However, little is known about the anti-inflammatory effect of RJ in microglial cells.
The aim of this study is to assess the anti-inflammatory effects of RJ in lipopolysaccharide- (LPS-) induced murine immortalized BV-2 cells and to explore the underlying molecular mechanisms.
Our results showed that in LPS-stimulated BV-2 cells, RJ significantly inhibited iNOS and COX-2 expression at mRNA and protein levels.
The mRNA expression of IL-6, IL-1β, and TNF-α was also downregulated by RJ in a concentration-dependent manner.
Additionally, RJ protected BV-2 cells against oxidative stress by upregulating heme oxygenase-1 (HO-1) expression and by reducing reactive oxygen species (ROS) and nitric oxide (NO) production.
Mechanistically, we found that RJ could alleviate inflammatory response in microglia by suppressing the phosphorylation of IκBα, p38, and JNK and by inhibiting the nucleus translocation of NF-κB p65.
These findings suggest that RJ might be a promising functional food to delay inflammatory progress by influencing the microglia function.
American Psychological Association (APA)
You, Meng-Meng& Chen, Yi-Fan& Pan, Yong-Ming& Liu, Yi-Chen& Tu, Jue& Wang, Kai…[et al.]. 2018. Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38JNK Signaling Pathways. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204217
Modern Language Association (MLA)
You, Meng-Meng…[et al.]. Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38JNK Signaling Pathways. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204217
American Medical Association (AMA)
You, Meng-Meng& Chen, Yi-Fan& Pan, Yong-Ming& Liu, Yi-Chen& Tu, Jue& Wang, Kai…[et al.]. Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38JNK Signaling Pathways. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204217