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Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation
Joint Authors
Sahebkar, Amirhossein
Yamthe Tchokouaha, Lauve Rachel
Tsouh Fokou, Patrick Valere
Bakarnga-via, Issakou
Gounoue Kamkumo, Raceline
Fekam Boyom, Fabrice
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) is the most hostile tumor in the central nervous system.
Unfortunately, the prognosis of GBM patients is poor following surgical interventions, chemotherapy, and radiotherapy.
Consequently, more efficient and effective treatment options for the treatment of GBM need to be explored.
Zerumbone, as a sesquiterpene derived from Zingiber zerumbet Smith, has substantial cytotoxic and antiproliferative activities in some types of cancer.
Here, we show that exposure of GBM cells (U-87 MG) to Zerumbone demonstrated significant growth inhibition in a concentration-dependent manner.
Zerumbone also induced apoptosis and caused cell cycle arrest of human GBM U-87 MG cells in the G2/M phase of the cell cycle.
In detail, the apoptotic process triggered by Zerumbone involved the upregulation of proapoptotic Bax and the suppression of antiapoptotic Bcl-2 genes expression as determined by qRT-PCR.
Moreover, Zerumbone enhanced the generation of reactive oxygen species (ROS), and N-acetyl cysteine (NAC), as an antioxidant, reversed the ROS-induced cytotoxicity of U-87 MG cells.
The Western blot analysis suggested that Zerumbone activated the NF-κB p65, which was partly inhibited by NAC treatment.
Collectively, our results confirmed that Zerumbone induces cytotoxicity by ROS generation.
Thus, the study raises the possibility of Zerumbone as a potential natural agent for treating GBM due to its ability to induce cytotoxicity.
American Psychological Association (APA)
Tsouh Fokou, Patrick Valere& Fekam Boyom, Fabrice& Gounoue Kamkumo, Raceline& Yamthe Tchokouaha, Lauve Rachel& Bakarnga-via, Issakou& Sahebkar, Amirhossein. 2020. Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204223
Modern Language Association (MLA)
Tsouh Fokou, Patrick Valere…[et al.]. Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1204223
American Medical Association (AMA)
Tsouh Fokou, Patrick Valere& Fekam Boyom, Fabrice& Gounoue Kamkumo, Raceline& Yamthe Tchokouaha, Lauve Rachel& Bakarnga-via, Issakou& Sahebkar, Amirhossein. Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204223