Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential
Joint Authors
Abdelrazek, Heba M. A.
Mahmoud, Manal M. A.
Tag, Hend M.
Greish, Sahar M.
Eltamany, Dalia A.
Soliman, Mohammed T. A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause.
The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolism.
Thirty healthy cyclic female Wistar rats were used in this experiment.
Ten females were sham-operated, and 20 females were subjected to ovariectomy.
Overiectomized (OVX) female rats were randomly divided into 2 groups: the control group (G1, OVX/casein) was fed a casein-based diet, and the second group (G2, OVX/soy) was fed a high soy isoflavone diet.
Both groups were compared to a sham-operated group (G3, sham/casein).
Treatments continued for 7 weeks.
Feed intake, weight gain, and lymphoid organ relative weights were recorded.
Some metabolic, immunological, and bone health-related parameters were measured.
Moreover, nitric oxide (NO), malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined.
Bone histopathology and immunohistochemistry to estrogen receptor alpha (ERα) were done.
Feeding soy to OVX females reduced feed intake, weight gain, relative lymphoid organ weight, and T-lymphocytes transformation.
Soy isoflavone administration normalized nearly all metabolic and immunological parameters to a level comparable to the sham group via oxidative stress amelioration and bone ERα promotion.
Soy isoflavones seemed to be good HRT in estrogen deprivation which modulated the appetite, weight gain, lipid profile, proinflammation, and bone turnover.
American Psychological Association (APA)
Abdelrazek, Heba M. A.& Mahmoud, Manal M. A.& Tag, Hend M.& Greish, Sahar M.& Eltamany, Dalia A.& Soliman, Mohammed T. A.. 2019. Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204241
Modern Language Association (MLA)
Abdelrazek, Heba M. A.…[et al.]. Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204241
American Medical Association (AMA)
Abdelrazek, Heba M. A.& Mahmoud, Manal M. A.& Tag, Hend M.& Greish, Sahar M.& Eltamany, Dalia A.& Soliman, Mohammed T. A.. Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204241